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David Perrin Research Group
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  • Chemically Enhanced DNAzymes and Aptamers
  • PET Radiolabels
  • Peptide Natural Products and Therapeutics

  • About the Perrin Research Lab

    We do fantastic things with chemistry to solve problems in biology. We’re tackling problems in cancer imaging and treatment, metal sensing, and antiviral agents made of peptides, DNA or both.  

  • Group Events

    While we work hard, we do find time to get together and have fun as a group as we celebrate achievements, publications, thesis defenses and graduations.

  • Synthesis

    A large part of our work relies on synthesizing novel building blocks with multiple heteroatoms including fluorine, boron, nitrogen, sulfur, phosphorus, oxygen, silicon, halogens, and an occasional selenium atom; these are used to explore new methods and create new molecules as probes for biology

  • Nucleic Acids

    We are pioneering the use of synthetically modified nucleosides for selecting cell-surface recognition aptamers, therapeutic DNAzymes for cleaving viral messenger RNA, and sensors for toxic metals.

  • Peptides

    Modified peptides, peptide natural products and new peptides inspired by Nature pique our synthetic interests and serve as new therapeutic leads. A major thrust in our lab is the use of amatoxins to explore antibody-drug conjugates and peptide drug conjugates – namely ATACs (amatoxin-tethered antibody conjugates) and PACs (peptide-amatoxin conjugates).

  • PET Imaging

    Non-invasive PET imaging is playing an increasingly important role in cancer diagnosis and staging as it allows sensitive and deep-tissue localization of tumors and metastases. In comparison to MRI or SPECT, PET combines very high sensitivity with dynamic spatio-temporal resolution to examine bio-distribution and clearance. In a study of 3,779 Canadian patients, PET imaging resulted […]

  • Stealth Projects

    We have a few skunkworks for turning “science fiction” into “science fact”: our lab maintains a culture of innovation, risk-​taking, and out-of-the-box thinking for innovation and impact that can change business as usual with totally new chemistry. We are always looking for students who want to create something new.

Peptide natural products                 18F-labeling / PET imaging         chemically modified aptamers            protein-like DNAzymes

JACS-Amanitin ACIE-2008-47-23

Highlights

  • Using synthetic organic and bioinorganic chemistry to create new biologic probes, imaging agents, and catalytic drugs
  • Over 130 Peer-reviewed publications in 24 years, h-index 41, over 3700 citations
  • 6 patents issued, 1 patent entering national phase and 3 provisional patents filed
  • Winner of a Michael Smith Senior Scholar Award 2010
  • 2015 TEVA Award for Biological Chemistry (CSC)
  • 2018 Bernard Belleau Award (CSC)
  • co-founder Alpha9Theranostics Inc.
  • Competitively awarded funding from NSERC, CIHR, CCSRI, and Genome-BC

 

David Perrin Research Group
Vancouver Campus
2036 Main Mall
Vancouver, BC Canada V6T 1Z1
Tel 604 822 0567
Website perrin.chem.ubc.ca
Email dperrin@chem.ubc.ca
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