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David Perrin Research Group
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  • DNAzymes and Aptamers
  • PET Radiolabels
  • Peptide Natural Products and Therapeutics

  • About the Perrin Research Lab

    We do fantastic things with chemistry to solve problems in biology. We’re tackling problems in cancer imaging and treatment, metal sensing, and antiviral agents made of peptides, DNA or both.  

  • Group Events

    While we work hard, we do find time to get together and have fun as a group as we celebrate achievements, publications, thesis defenses and graduations.

  • Synthesis

    A large part of our work relies on synthesizing novel building blocks with multiple heteroatoms including fluorine, boron, nitrogen, sulfur, phosphorus, oxygen, silicon, halogens, and an occasional selenium atom; these are used to explore new methods and create new molecules as probes for biology

  • Nucleic Acids

    We are pioneering the use of synthetically modified nucleosides for selecting cell-surface recognition aptamers, therapeutic DNAzymes for cleaving viral messenger RNA, and sensors for toxic metals.

  • Peptides

    Modified peptides, peptide natural products and new peptides inspired by Nature pique our synthetic interests and serve as new therapeutic leads.

  • PET Imaging

    We have invented trifluoroborates as captors of 18F-fluoride for one-step labeling of biomolecules for PET imaging. Above is our work on dual-mode imaging agents for PET imaging and fluorescent-guided surgery

  • Stealth Projects

    We have a few skunkworks for turning “science fiction” into “science fact”: our lab maintains a culture of innovation, risk-​taking, and out of the box thinking for innovation and impact that can change business as usual with totally new chemistry. We are always looking for students who want to create something new.

Peptide natural products                 18F-labeling / PET imaging         chemically modified aptamers            protein-like DNAzymes

JACS-Amanitin ACIE-2008-47-23

Highlights

  • Using synthetic organic and bioinorganic chemistry to create new biologic probes, imaging agents, and catalytic drugs
  • Over 110 Peer-reviewed publications in 22 years, h-index 36, over 3400 citations
  • 6 patents issued, 1 patent entering national phase and 3 provisional patents filed
  • Winner of a Michael Smith Senior Scholar Award 2010
  • 2015 TEVA Award for Biological Chemistry (CSC)
  • 2018 Bernard Belleau Award (CSC)
  • co-founder Alpha9Theranostics Inc.
  • Competitively awarded funding from NSERC, CIHR, CCSRI, and Genome-BC

 

David Perrin Research Group
Vancouver Campus
2036 Main Mall
Vancouver, BC Canada V6T 1Z1
Tel 604 822 0567
Website perrin.chem.ubc.ca
Email dperrin@chem.ubc.ca
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