Publication List

Cover issues: from time to time, the Perrin lab has had the honor of having its work featured on the covers of various journals – shown below are some of our best “artwork”…more to come in the years ahead!

List of publications:

†*128) Diphenylphosphinylhydroxylamine (DPPH) Affords Late-Stage S-imination to access free-NH Sulfilimines and Sulfoximines, Shanal Gunasekera, Alla Pryyma, Jimin Jung, Rebekah Greenwood, Brian O. Patrick, and David M. PerrinAngewandte Chemie 2024 on line.

127) 5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2′-bis-Indole Peptide Staples: Application to Melanotan-II Mihajlo Todorovic, Antoine Blanc, Zhou Wang, Jerome Lozada, Juliette Froelich, Jutta Zeisler, Chengcheng Zhang, Helen Merkens, Francois Benard, David M. Perrin*, Chem. Eur. J. 2024 e202304270.

126) Toward Tryptathionine-stapled OBOC Libraries: Solid Phase Synthesis of a Bioactive Stapled Octreotate Analog, Antoine Blanc, Mihajlo Todorovic, Iulia Dude, Helen Merkens, François Bénard, and David M. Perrin* Org. Biomol. Chem. 2023 21, 8112–8116.

125) Efficient Synthesis of (S)- and (R)-beta Proline, Shambhu Deo Chandra, Ethan W.F. Fung, and David M. Perrin* Synthesis 2023 on line.

124) Imidazolium-Methylene-Trifluoroborate: A Novel Radioprosthetic Group For 18F- Radiotracer Development Validated with Preclinical PET Imaging of PSMA in Mice, Jerome Lozada, Hsiou-Ting Kuo, Wen Xuan Lin, Kuo-Shyan Lin, François Bénard, and David M. Perrin* J. Labeled Compounds and Radiopharmaceuticals2023 66: 130-137.

123) Salt Metathesis: Tetrafluoroborate Anion Rapidly Fluoridates Organoboronic Acids to give Organotrifluoroborates, Jerome Lozada, Wen Xuan Lin, Rosana M. Cao-Shen, Ruyin Astoria Tai and David M. Perrin* Angewandte Chemie 2023.

122) Rationally Designed Amanitins Achieve Enhanced Cytotoxicity, Mihajlo Todorovic, Paul Rivollier, Antonio A. W. L. Wong, Zhou Wang, Alla Pryyma, Tuan Trung Nguyen, Kayla C. Newell, Juliette Froelich and David M. Perrin* J. Med. Chem. 2022 on line ASAP.

121) Selection of M2+-independent RNA-cleaving DNAzymes with Side-chains Mimicking Arginine and Lysine, by Somdeb Paul, Antonio A. W. L. Wong, Leo T. Liu, and David M. Perrin* on line ChemBioChem 2022.

120) Synthesis and Preliminary Evaluation of Octreotate Conjugates of Bioactive Synthetic Amatoxins for Potential Targeted Therapy of Somatostatin-expressing Cancers, Alla Pryyma, Kaveh Matinkhoo, Yong Jia Bu, Zhengxing Zhang, Helen Merkens, Francois Benard, and David M. Perrin* RSC Chemical Biology 2022 3 69-78.

119) Light-Activated Cell Death via Pol II Inhibition: Synthesis and Evaluation of “Ama-Flash”, a Photocaged Amatoxin Prodrug, Kaveh Matinkhoo, Alla Pryyma, Antonio A. W. L. Wong, David M. Perrin* on line Chem. Comm. 2021

118) Chiral Benzothiazole Monofluoroborate Featuring Chiroptical and Oxygen-Sensitizing Properties: Synthesis and Photophysical Studies, Omar Sadek, Laura Abad Galán, Frédéric Gendron, Bruno Baguenard, Stephan Guy, Amina Bensalah-Ledoux, Boris Le Guennic*, Olivier Maury*, David M. Perrin, and Emmanuel Gras*, J. Org. Chem., 2021 asap.

117) Suzuki-Miyaura coupling of Benzoyl-MIDA boronate ester – a Preliminary report on Scope and Limitations, Samson Lai, Noah Takaesu, Wen Xuan Lin, David M. Perrin* Tetrahedron Lett. 2021 74 153147.

116) Design, synthesis, and biochemical evaluation of alpha-amanitin derivatives containing analogs of the trans-hydroxyproline residue for potential use in antibody-drug conjugates, Kaveh Matinkhoo, Antonio A. W. L. Wong, Chido M. Hambira, Brandon Kato, Charlie Wei, Christoph Müller, Torsten Hechler, Alexandra Braun, Francesca Gallo, Andreas Pahl* David M. Perrin* Chem. Eur. J. 202127: 10282–10292.

115) Scaling amatoxin synthesis with an improved route to (2S,3R,4R)-dihydroxyisoleucine exemplified by a toxic, clickable α-amanitin analog, Chido M. Hambira, Kaveh Matinkhoo, Alla Pryyma, Brian O. Patrick, and David M. Perrin*, J. Org. Chem. 2021 86: 5362-5370.

114) High-contrast CXCR4-targeted 18F-PET imaging using a potent and selective antagonist, Daniel Kwon, Jerome Lozada, Zhengxing Zhang, Jutta Zeisler, Richel Poon, Chengcheng Zhang, Áron Roxin, Kuo-Shyan Lin, David Perrin, Francois Benard,  Mol. Therapeutics 2021 18: 187-197.

113) Rapid, High-Yielding Solid-phase Synthesis of Cathepsin-B Cleavable Linkers for Targeted Cancer Therapeutics, Alla Pryyma, Shanal Gunasekera, Joshua Lewin, David M. Perrin* Bioconjug. Chem. 2020 31: 2685-90.

112) A hypothesis for examining dihydroxyacetone, the active component in sunless tanning products, as a topical prophylactic against SARS-COV-2 transmission David M. Perrin* Medical Hypotheses 2020 144 110280 1-3.

111) Meeting key synthetic challenges in amanitin synthesis with a new cytotoxic analog: 5′-hydroxy-6′-deoxy-amanitin, Alla Pryyma, Kaveh Matinkhoo, Antonio A. W. L. Wong David M. Perrin* Chemical Science 2020 11: 11927–11935.

110) Recent developments in catalytic amide bond formation, Mihajlo Todorovic and David M. Perrin*, Peptide Science 2020 112: e24210.

109) FlICk (Fluorescent Isoindole Crosslinking) for Peptide Stapling, Mihajlo Todorovic and David M. Perrin  Methods in Enzymology 2020 639: 313-32.

108) Synthesis and 18F-radiolabeling of thymidine-AMBF conjugates, Antonio A. W. L. Wong, Jerome Lozada, Mathieu Lepage, Chengcheng Zhang, Helen Merkens, Jutta Zeisler, Kuo-Shyan Lin, François Bénard, and David M. Perrin RSC Medicinal Chem. 2020 11: 569-576.

107) Pharmacokinetics, radiation dosimetry, acute toxicity and automated synthesis of [18F]AmBF3-TATE, Joseph Lau, Jinhe Pan, Etienne Rousseau, Carlos F. Uribe, Sudhakara Reddy Seelam, Brent W. Sutherland, David M. Perrin, Kuo-Shyan Lin and François Bénard EJNMMI Research 2020 10:25 1-10.

106) Straightforward convergent access to 2-arylated polysubstituted benzothiazoles, Omar Sadek, David M. Perrin, Emmanuel Gras, Tetrahedron 2020 76: 130982 1-8.

105) Toward 18F-Labeled Theranostics: A Single Agent that can be Labeled with 18F, 64Cu, or 177Lu, Mathieu L. Lepage, Hsiou-Ting Kuo, Aron Roxin, Sungjoon Huh, Zhengxing Zhang, Rajaguru Kandasamy, Helen Merkens, Joel O. Kumlin, Alan Limoges, Stefan K. Zeisler, Kuo-Shyan Lin, François Bénard, and David M. Perrin ChemBioChem 2020 21: 943-947.

104) 18F-Labeled Cyclized α-Melanocyte-Stimulating Hormone Derivatives for Imaging Human Melanoma Xenograft with Positron Emission Tomography, Chengcheng Zhang, Zhengxing Zhang, Helen Merkens, Jutta Zeisler, Nadine Colpo, Navjit Hundal-Jabal, David M. Perrin, Kuo-Shyan Lin, François Bénard Scientific Reports 2019 9: 13575.

103) Synthesis and Activation of Bench-Stable Fluoropyrroloindolines as Latent Electrophiles for the Synthesis of C-2 Thiol-substituted Tryptophans and C-3a-substituted Pyrroloindolines, Alla Pryyma, Yong Jia Bu, Yonnie Wai, and David M. Perrin Org. Lett. 2019 20: 8234-8238.102) Fluorescent Isoindole Crosslink (FlICk) Synthesis – a Rapid, User-friendly, High-yielding Reaction for Structuring Peptides for Enhanced Biological Activity, Mihajlo Todorovic, Katerina Schwab, Jutta Zeisler, Chengcheng Zhang, Francois Benard, David M. Perrin Angewandte Chemie 2019 58 14120–14124.

101) [18F]AMBF3-DOTA LLP2A for improved PET imaging of VLA-4 overexpression in melanoma, Áron Roxin, Chengcheng Zhang, Sungjoon Huh, Mathieu Lepage, Zhengxing Zhang, Kuo-Shyan Lin, François Bénard, David M. Perrin Bioconjugate Chemistry 2019 30: 1210-1219.

100) Unsymmetrical Diaryliodonium Phenyltrifluoroborate Salts: Synthesis, Structure and Fluorination, Omar Sadek, David M. Perrin, Emmanuel Gras J. Fluor. Chem. 2019 222: 68-74.99) Solid-phase synthesis and biological activity of a novel phalloidin derivative, Antoine Blanc, Mihajlo Todorovic, and David M Perrin Chem. Commun. 2019 55: 385 – 388.98) One-step 18F-labeling and preclinical evaluation of PSMA-targeting trifluoroborate probes: varying structure and prosthetic group for prostate cancer imaging, Hsiou-Ting Kuo, Mathieu L. Lepage, Kuo-Shyan Lin, Jinhe Pan, Zhengxing Zhang, Zhibo Liu, Alla Pryyma, Chengcheng Zhang, Helen Merkens, Aron Roxin, David M. Perrin, François Bénard, J. Nucl. Med. 2019 60: 1160-1166.

97) Expanding the Balz-Schiemann Reaction: organotrifluoroborates serve as competent sources of fluoride ion for fluoro-dediazoniation,Tharwat Mohy El Dine, Omar Sadek, Emmanuel Gras,* David M. Perrin, Chem. Eur. J. 2018 56: 14933-14937.

96) Synthesis of 3a-hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxamide, an oxidation product of tryptophan present in natural products, Antoine Blanc and David M. Perrin J. Peptide Science 2018 111 e24082.

95) Organotrifluoroborates as prosthetic groups for Single-Step F18-Labeling of Molecularly Complex Molecules, David M. Perrin Current Opinion in Chemical Biology 2018 45:86–94.

94) Melanoma imaging using 18F-labeled α-melanocyte-stimulating hormone derivatives with positron emission tomography, Chengcheng Zhang, Zhengxing Zhang, Kuo-Shyan Lin, Joseph Lau, Jutta Zeisler, Nadine Colpo, David Perrin, Francois Benard Molecular Pharmaceutics 2018 15: 2116-2122.

93) Solid-phase synthesis of amanitin derivatives and preliminary evaluation of cellular uptake and toxicity, Antoine Blanc, David Dietrich and David M. Perrin J. Peptide Science 2018 111 e20450 1-8.

92) Recent advances in fluorine-18 radiochemistry: Focus on B-18F, Si-18F, Al-18F and C-18F radiofluorination via spirocyclic iodonium ylides (invited review), Ralf Schirrmacher, Vadim Bernard-Gauthier, Mathieu L. Lepage, Bjoern Waengler, Justin J. Bailey, Steven H. Liang, David Perrin, Neil Vasdev, J. Nucl. Med. 2018 59: 568-572.

91) Microfluidic radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: a potential PET tracer for clinical imaging of somatostatin receptors, Ksenia Lisova, Maxim Sergeev, Susan Evans-Axelsson, Andreea D. Stuparu, Seval Beykan, Jeffrey Collins, Jason Jones, Michael Lassmann, Ken Herrmann, David Perrin, Jason T. Lee*, Roger Slavik*, Michael van Dam* Nucl. Med. Biol. 2018 61: 36-44.

90) A densely modified M2+-Independent DNAzyme capable of efficient all-RNA cleavage and mammalian cell membrane penetration, Yajun Wang, Erkai Liu, Curtis H. Lam, and David M. Perrin Chemical Science 2018 9: 1813-1821.89) Evaluation of 18F-labeled LLP2A-trifluoroborate conjugates as VLA-4 (α4β1 integrin) specific radiotracers for PET imaging of melanoma Áron Roxin, Chengcheng Zhang, Sungjoon Huh, Mathieu L. Lepage, Zhengxing Zhang, Kuo-Shyan Lin, François Bénard, David M. Perrin Nucl. Med. and Biol. 2018 61: 11-20.

88) Synthesis of the death-cap mushroom toxin α-Amanitin, Kaveh Matinkhoo, Alla Pryyma, Mihajlo Todorovic, Brian O. Patrick, and David M. Perrin J. Am Chem. Soc. 2018 140: 6513-6517.87) Direct access to MIDA acylboronates via mild oxidation of MIDA vinylboronates, Mathieu L. Lepage, Samson Lai, Nicolas Peressin, Romain Hadjerci, Brian O. Patrick, and David M. Perrin Angewandte Chemie 2017 56:15257-61.

86) Whole cell SELEX of modified aptamers with tyrosine-like sidechains against live bacteria, Marlene Renders, Emily Miller, Curtis Lam, and David M. Perrin Org. Biomol. Chem. 2017 15: 1980-1989. PMID 28009914

85) A systematic study of constraints imposed by modified nucleosides with protein-like side chains: thermal stability, base pairing selectivity, and replication fidelity of imidazole-dA, guanidino-allyl-dU, and amino-allyl-dC: Yajun Wang, Nicole Ng, Erkai Liu, Curtis H. Lam, David M. Perrin Org. Biomol. Chem. 2017 15: 610-618. PMID 27942671

84) Peroxymonosulfate anion (Oxone) efficiently oxidizes Nα-protected tryptophan and Nα-protected tryptophanyl-dipeptides in acetone to hexahydropyrroloindoline-containing synthons suitable for peptide synthesis and subsequent tryptathionylation, Antoine Blanc, Fan Xia, Mihajlo Todorovic, and David M. Perrin Amino Acids 2017 49: 407-414. PMID 27866290

83) Facile synthesis and 18F-radiolabeling of α4β1-specific LLP2A-aryltrifluoroborate peptidomimetic conjugates, Daniel Walker, Ying Li, Áron Roxin, Paul Schaffer, Michael J. Adam, and David M. Perrin Bioorg. Med. Chem. Lett. 2016 26:5126-5131. PMID 27623550

82) Radiolabeled B9958 Derivatives for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography: Effect of the Radiolabel-Chelator Complex on Biodistribution and Tumor Uptake, Zhengxing Zhang, Guillaume Amouroux, Jinhe Pan, Silvia Jenni, Jutta Zeisler, Chengcheng Zhang, Zhibo Liu, David M. Perrin, Francois Benard, Kuo-Shyan Lin, Molecular Pharmaceutics 2016 13: 2823-32 PMID 27348517

81) 18F-Organotrifluoroborates as Radioprosthetic Groups for PET Imaging: From Design Principles to Preclinical Application, David M. Perrin, Acc. Chem. Res. 2016 49: 1333-1343 PMID 27054808

80) From Unorthodox to Established: The Current Status of F-18-Trifluoroborate- and F-18-SiFA-Based Radiopharmaceuticals in PET Nuclear Imaging, Vadim Bernard-Gauthier, Justin J. Bailey, Zhibo Liu, Bjoern Wangler, Carmen Wangler, Klaus Jurkschat, David M. Perrin, Ralf Schirrmacher, Bioconjugate Chem. 2016 27: 267-279. PMID: 26566577

79) Synthesis and evaluation of F-18-trifluoroborate derivatives of triphenylphosphonium for myocardial perfusion imaging, Zhengxing Zhang, Sylvia Jenni, Chengcheng Zhang, Helen Merkens, Joseph Lau, Zhibo Liu, David M. Perrin, Francois Benard, Kuo-Shyan Lin, Bioorganic and Medicinal Chemistry Letters 2016, 26: 1675-1679 PMID 26922139

78) Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates, Erkai Liu, Curtis Lam, David M. Perrin, Molecules 2015 20: 13591-13602 PMID: 26213912

77) One-step 18F labeling of biomolecules using organotrifluoroborates, Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Maral Pourghiasian, Dale O Kiesewetter, David M. Perrin, Xiaoyuan Chen, Nature Protocols 2015 9: 1423-32. PMID 26313478

76) Synthesis of a cytotoxic amanitin for biorthogonal conjugation, Liang Zhao, David J. Dietrich, Jonathan P. May, Antoine Blanc, Anastak Loonchanta, Kaveh Matinkhoo, Alla Pryyma, David M. Perrin, ChemBioChem 2015 16:1420-1425. PMID: 2604318475) Trimeric radiofluorinated sulfonamide derivatives to achieve in vivo selectivity for carbonic anhydrase IX-targeted PET imaging, Joseph Lau, Zhibo Liu, Kuo-Shyan Lin, Jinhe Pan, Zhengxing Zhang, Daniela Vullo, Claudiu T. Supuran, David M. Perrin, and Francois Benard J. Nucl. Med. 2015 56: 1434-40.

74) 18F-Trifluoroborate Derivatives of [Des-Arg10]-Kallidin for Imaging Bradykinin B1 Receptor Expression with Positron Emission Tomography, Zhibo Liu, Guillaume Amouroux, Zhengxing Zhang, Jinhe Pan, Navjit Hundal-Jabal, Nadine Colpo, Joseph Lau, David Perrin, Francois Benard, Kuo-Shyan Lin Molecular Pharmaceutics 2015 12: 974-82. PMID: 25629412

73) MJ9: a novel radiofluorinated bombesin derivative for prostate cancer imaging, Maral Pourghiasian, Zhibo Liu, Jinhe Pan, Nadine Colpo, Kuo-Shyan Lin, David M. Perrin, Francois Benard Bioorg. Med Chem. 2015 23:1500-6. PMID: 25757604

72) From Minutes to Years: Predicting Solvolysis Rates for Organotrifluoroborates, Zhibo Liu, Daniel Chao, Ying Li, Richard Ting, Jihyoon Oh, David M. Perrin Chem. Eur. J.2015 21, 3924-3928. PMID: 25639468

71) A Method for Selecting Modified DNAzymes Without PCR Amplification of Modified DNA, Marleen Renders, Emily Miller, Marcel Hollenstein, and David M. Perrin Chemical Communications: 2015 51: 1360-1362. PMID: 25487111

70) Designing Kinetically Stable Aryltrifluoroborates as 18F-Capture Agents for PET Imaging: A Physical Organic Approach, Zhibo Liu, Richard Ting, Ying Li, and David M. Perrin, J. Phys. Org. Chem. 2015 28:210-214.

69) Dual Mode Fluorescent 18F-PET Tracers: Efficient modular synthesis of rhodamine-[cRGD]2-[18F]-organotrifluoroborate, rapid and high yielding 18F-labeling at high specific activity with correlated In vivo PET Imaging and Ex vivo fluorescence Zhibo Liu, Mark Alex Radtke, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, David M. Perrin Bioconjugate Chemistry 2014 25:1951-62. PMID: 25265337

68) A Broadly Applicable One-step Method for 18F-labelling, Zhibo Liu, Maral Pourghiasian, M. Alex Radtke, Joseph Lau, Jinhe Pan, Donald Yapp, Kuo-Shyan Lin, Francois Benard, and David M. Perrin Angewandte Chemie 2014 53: 11876–11880. PMID: 25196467

67) Base-promoted Protodeboronation of 2,6-Disubstituted Arylboronic Acids, Jerome Lozada, Zhibo Liu, David M. Perrin J. Org. Chem. 2014 79: 5365-8. PMID: 24826787

66) Preclinical evaluation of a high affinity 18F-trifluoroborate octreotate derivative for somatostatin receptor imaging, Zhibo Liu, Maral Pourghiasian, François Bénard, Jinhe Pan, Kuo-Shyan Lin, David M. Perrin J. Nucl. Med. 2014 55: 1499-1505. PMID: 24970911

65) A new 18F-heteroaryltrifluoroborate radio-prosthetic with greatly enhanced stability that is labelled by 18F-19F-isotope exchange in good yield at high specific activity, Zhibo Liu, Navjit Hundal-Jabal, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, Francois Benard, David M. Perrin MedChemComm 2014 5: 171-179.

64) A Pyrimidopyrimidine Janus-AT Nucleoside with Improved Base-Pairing Properties to both A and T with a DNA Duplex: The Stabilizing Effect of a Second Endocyclic Ring Nitrogen, Eric Largy, Wenbo Liu, Abid Hasan, and David M. Perrin, Chem. – Eur. J. 2014 20: 1495-99. PMID: 24443271

63) Dual isotope labeling of oligonucleotides with aryltrifluoroborate via copper(I) catalyzed cycloaddition for PET imaging, Ying Li, Paul Schaffer, and David Perrin Bioorg. Med. Chem. Lett. 2013 23: 6313-6316. PMID: 24144852

62) One-Step 18F-Labeling of Dimeric CycloRGD at High Specific Activity for Functional PET Imaging of Tumors in Mice, Ying Li, Zhibo Liu, May Q. Wong, Kuo-Shyan Lin, Donald Yapp, David M. Perrin Nucl. Med. and Biol. 2013 40: 959-966. PMID: 24090672

61) Base-Pairing Behavior of a Carbacyclic Janus-AT Nucleoside Analogue Capable of Recognizing A and T within a DNA Duplex, Eric Largy, Wenbo Liu, Abid Hasan, and David M. Perrin, ChemBioChem. 2013 14: 2199-2208. PMID: 24115365

60) Kit-like 18F-labeling of RGD-19F-Arytrifluroborate in high yield and at extraordinarily high specific activity with preliminary in vivo tumor imaging Zhibo Liu, Ying Li, Jerome Lozada, May Q. Wong, Jennifer Greene, Kuo-Shyan Lin, Donald Yapp, David M. Perrin, Nucl. Med. and Biol. 2013 40: 841–849. PMID: 23810487

59) Towards the Combinatorial Selection of Sequence Specific RNaseA Mimics, Marcel Hollenstein, Christopher J. Hipolito, Curtis H. Lam and David M. Perrin, ACS Combinatorial Science 2013 15:174-182. PMID: 23485334

58) One-step and One-Pot-Two-Step Radiosynthesis of Cyclo-RGD-18F-Aryltrifluoroborate Conjugates for Functional Imaging, Ying Li, Jinxia Guo, Shiqing Tang, Lixin Lang, Xiaoyuan Chen, and David M. Perrin American Journal of Nuclear Medicine and Molecular Imaging 2013 3:44-56. PMID: 23342300

57) Stoichiometric Leverage: Rapid [18F]-Aryltrifluoroborate Radiosynthesis at Exceptionally High Specific Activity For Click Conjugation, Zhibo Liu, Ying Li, Jerome Lozada, Paul Schaffer, Thomas J. Ruth, Michael J. Adam, David M. Perrin. Angewandte Chemie 2013 52: 2304-7. PMID: 23315972

56) Alkyne-18F-ArBF3 for One-Pot Click 18F-Labeling of Bombesin for in vivo PET Imaging of Tumors Expressing the GRP-Receptor, Ying Li, Zhibo Liu, Maral Pourghiasian, Kuo-Shyan Lin, Paul Schaffer, Francois Benard, David M. Perrin, American Journal of Nuclear Medicine and Molecular Imaging 2013 3:57-70. PMID: 23342301

55) Rapid, One-Step, High Yielding 18F-Labeling of an Aryltrifluoroborate Bioconjugate by Isotope Exchange at Very High Specific Activity, Zhibo Liu, Ying Li, Jerome Lozada, Kuo-Shyan Lin, Paul Schaffer, David M. Perrin, J. Labeled Compounds and Radiopharmaceuticals 2012 14: 491-97.

54) Stereoselective synthesis of Brevianamide E, Liang Zhao, Jonathan P. May, Jack Huang, David M. Perrin, Org. Lett. 2012 14: 90-93. PMID: 22126228

53) Life- Like but Not Living: Modified Nucleic Acids for Binding and Catalysis, David M. Perrin (Invited Review), Comprehensive Polymer Science 2012.

52) Towards Kit-Like 18F-Labeling of Marimastat, a Reversible MMPI, for in vivo PET Imaging of Cancer Associated Matrix Metalloproteases, Ying Li, Richard Ting, Curtis W. Harwig, Caroline L. Bellac, Philipp F. Lange, Ulrich auf dem Keller, James A. H. Inkster, Paul Schaffer, Michael J. Adam, Thomas J. Ruth, Christopher M. Overall, David M. Perrin, MedChemComm 2011 2: 942-6.

51) A divalent metal-dependent self-cleaving DNAzyme with a tyrosine-like side chain Curtis H. Lam, Christopher J. Hipolito, Marcel Hollenstein and David M. Perrin Org. Biomol. Chem. 2011 9: 6949-54. PMID: 21670811

50) Protein-Inspired Modified DNAzymes: Dramatic Effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA Mimicking DNAzymes, Christopher J. Hipolito, Marcel Hollenstein, Curtis H. Lam, David M. Perrin, Org. Biomol. Chem. 2011 9: 2266-2273. PMID: 21311779

49) [18F]-Marimastat-aryltrifluoroborate: A non-covalent peptidic metalloproteinase inhibitor for in vivo PET imaging in cancer, Ulrich auf dem Keller, Caroline L. Bellac, Philipp F. Lange, Ying Li, Yuan-mei Lou, Richard Ting, Curtis Harwig, Reinhild Kappelhoff, Cal Roskelley, Shoukat Dedhar, Michael J. Adam, Thomas J. Ruth, Francois Benard, David M. Perrin, Christopher M. Overall, Cancer Research 2010 70: 7562-7569. PMID: 20729277

48) Introduction of Guanidinium Modified Oligonucleotides with Enhanced Target Affinity to the Substrate Binding Regions of DNAzyme 10-23: Implications for DNAzyme Design, Curtis Lam and David M. Perrin, Bioorg. Med Chem. Lett. 2010 20: 5119-5122. PMID: 20678934

47) A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage, Marcel Hollenstein, Christopher J. Hipolito, Curtis H. Lam and David M. Perrin, ChemBioChem 2009 10: 1988-1992. PMID: 1959118

46) Investigation of the Catalytic Mechanism of a Synthetic DNAzyme with Protein-like Functionality: An RNaseA Mimic? Jason M. Thomas, Jun-Ki Yoon, and David M. Perrin, J. Am. Chem. Soc. 2009 131: 5648–5658. PMID: 20560639

45) Hydrolytic stability of Nitrogenous-Heteroaryltrifluoroborates under Aqueous Conditions at Neutral pH, Ying Li, Ali Asadi, and David M. Perrin, J. Fluorine Chem. 2009 130: 377-382.

44) Probing General Acid Catalysis in the Hammerhead Ribozyme, Jason M. Thomas and David M. Perrin, J. Am. Chem. Soc2009 131: 1135-1143. PMID: 19154176

43) A Self-Cleaving DNA Enzyme Modified with Amines, Guanidines, and Imidazoles Operates Independently of Divalent Metal Cations (M2+), Marcel Hollenstein, Christopher J. Hipolito, Curtis Lam and David M. Perrin, Nucl. Acids. Res. 2009 37: 1638–1649. PMID: 19153138

42) The G^C Quartet – A Novel DNA Base Hybrid: Synthesis, Structural Analysis, and Self Organization, Ali Asadi, Brian O. Patrick, and David M. Perrin J. Am. Chem. Soc. 2008 130: 12860-12861. PMID: 18767852

41) Probing General Base Catalysis in the Hammerhead Ribozyme, Jason M. Thomas, and David M. Perrin, J. Am. Chem. Soc. 2008 130: 15467-75. PMID: 18950173

40) Synthesis and Enzymatic Incorporation of Modified Deoxyadenosine Triphosphates, Curtis Lam, Christopher Hipolito, and David M. Perrin, Eur. J. Org. Chem. 2008: 4915-4923.

39) Towards [18F]-Labeled Aryltrifluoroborate Radiotracers – In Vivo PET Imaging of Stable Aryltrifluoroborate Clearance in Mice, Richard Ting, Curtis Harwig, Ulrich auf dem Keller, Siobhan McCormick, Pamela Austin, Christopher M. Overall, Michael J. Adam, Thomas J. Ruth, and David M. Perrin, J. Am. Chem. Soc. 2008 130: 12045-12055. PMID: 18700764

38) Substituent Effects on Aryltrifluoroborate Solvolysis in Water: Implications for Suzuki-Miyaura Coupling and the Design of Stable 18F-Labeled Aryltrifluoroborates for Use in PET Imaging Richard Ting, Curtis Harwig, Justin Lo, Ying Li, Michael J. Adam, Thomas J. Ruth, and David M. Perrin, J. Org. Chem. 2008 73: 4662-4670. PMID: 18489162

37) A Highly Selective DNA Enzyme Sensor for Mercuric Cations, Marcel Hollenstein, Chris Hipolito, Curtis Lam, David Dietrich, and David M. Perrin, Angewandte Chemie 2008 47: 4346-4350. PMID: 18435522

36) Synthesis and characterization of 2,6-difluoro-4-carboxyphenylboronic acid and a biotin derivative thereof as captors of anionic aqueous [18F]-fluoride for the preparation of [18F/19F]-labeled aryltrifluoroborates with high kinetic stability, Curtis Harwig, Richard Ting, Michael J. Adam, Thomas J. Ruth, and David M. Perrin, Tetrahedron Letters 2008 49: 3152-56.

35) Synthesis, purification, and aqueous stability of a fluorescent [18F]-labeled aryltrifluoroborate, Richard Ting, Justin Lo, Michael J. Adam, Thomas J. Ruth, and David M. Perrin, J. Fluorine Chemistry 2008 129: 349-358.

34) Intra-annular Savige-Fontana reaction: One Step Conversion of One Class of Monocyclic Peptides into a Another Class of Bicyclic Peptides, Jonathan P. May and David M. Perrin Chem. Eur. J. 2008 14: 3404-3409. PMID: 18283698

33) Synthesis, Characterization, and in vitro Evaluation of Pro2-Ile3-S-Deoxo-Amaninamide and Pro2-D-allo-Ile3-S-Deoxo-Amaninamide; Implications for Structure Activity Relationships in Amanitin Conformation and Toxicity. Jonathan P. May, Pierre Fournier, Brian O. Patrick, and David M. Perrin Chem. Eur. J. 2008 14: 3410-3417. PMID: 18307186

32) Tryptathionine Bridges in Peptide Synthesis, Jonathan P. May and David M. Perrin Peptide Science (Invited Review) 2007 5: 714-724. PMID: 17626299

31) Kinetic Characterization of a Cis- and Trans-acting M2+-Independent DNAzyme that depends on synthetic RNaseA-like Functionality: Burst Phase Kinetics from the Coalescence of Two Active DNAzyme Folds, Richard Ting, Jason M. Thomas, and David M. Perrin Can. J. Chem. 2007 85: 313-329.

30) Janus-AT Bases: Synthesis, Self-Assembly, and Solid State Structures, Ali Asadi, Brian O. Patrick, and David M. Perrin J. Org. Chem. 2007 72: 466-475. PMID: 1722196329) Diastereoselectivity in the synthesis of syn-cis 3a-hydroxypyrrolo[2,3-b]indoline N’-methyl-dipeptide methyl esters, Jonathan P. May and David M. Perrin Synthesis 2006 20: 3403-3406.

28) Active Site Labeling of G8 in the Hairpin Ribozyme: Mechanistic Implications for General Base Catalysis, Jason M. Thomas and David M. Perrin J. Am. Chem. Soc. 2006 128: 16540-16545. PMID: 17177403

27) Arylfluoroborates and Alkylfluorosilicates as Potential PET Imaging Agents: High Yielding Aqueous Biomolecular 18F-Labeling, Richard Ting, Michael J. Adam, Thomas J. Ruth, and David M. Perrin, J. Am. Chem. Soc. 2005 127: 13094-13095. PMID: 16173707

26) High yielding synthesis of 3a-hydroxy-pyrrolo[2,3-b]indoline dipeptide methyl esters: Synthons for expedient introduction of the hydroxypyrroloindoline moiety into larger peptide-based natural products and for the creation of tryptathionine bridges, Jonathan P. May, Pierre Fournier, Jonathan Pellicelli, Brian O. Patrick, and David M. Perrin, J. Org. Chem 2005 70: 8424-8430. PMID: 16209587

25) Substrate Specificity and Kinetic Framework of a DNAzyme with an Expanded Chemical Repertoire: a Putative RNaseA Mimic that Catalyzes RNA Hydrolysis Independent of a Divalent Metal Cation, Richard Ting, Jason M. Thomas, Leonard Lermer, and David M. Perrin, Nucl. Acids Res. 2004 32: 6660-6672. PMID: 15625232

24) Selection and Characterization of DNAzymes with Synthetically Appended Functionalities: A Case of a Synthetic RNaseA Mimic, Richard Ting, Leonard Lermer, Jason Thomas, Yoann Roupioz, and David M. Perrin, (Invited Paper), Pure Appl. Chem. 2004 76: 1571-1577.

23) Triggering DNAzymes with Light: a Photoactive C8-Thioether Linked Adenosine, Richard Ting, Leonard Lermer, and David M. Perrin, J. Am. Chem. Soc. 2004 126: 12720-12721. PMID: 15469235

22) Covalent Schiff Base Catalysis and Turnover by a DNAzyme AP Lyase, Jonathan P. May, Richard Ting, Leonard Lermer, Jason M. Thomas, Yoann Roupioz, and David M. Perrin, J. Am. Chem. Soc. 2004 126: 4145-4156. PMID: 15053604

21) High affinity DNAzyme-based ligands for transition metal cations – a prototype sensor for Hg2+, Jason M. Thomas, Richard Ting, and David M. Perrin, Org. Biomol. Chem. – Royal Society 2004 2: 307-312. PMID: 14747858

20) Efficient Synthesis of Isotopically Pure ICAT Reagents, Anupama Patel and David M. Perrin, Bioconjug. Chem. 2004 15: 224-230. PMID: 1473360

19) Toward an RNaseA Mimic: A DNAzyme with Imidazoles and Cationic Amines, Leonard Lermer, Yoann Roupioz, Richard Ting, and David M. Perrin, J. Am. Chem. Soc. 2002 124: 9960-9961. PMID: 12188639

18) Incorporation of 8-Histaminyl-deoxyadenosine [8-(2-(4-Imidazolyl)ethylamino)-2’deoxyribo-adenosine] into Oligodeoxyribonucleotides by Solid Phase Phosphoramidite Coupling, Leonard Lermer, John Hobbs, and David M. Perrin, Nucleosides, Nucleotides, and Nucleic Acids 2002 21: 651-664. PMID: 1250228

Journals (from my postdoctoral work where I am corresponding author)

17) Triple-Helix Induced Photolysis of B-DNA in the Presence of 5-(2-(N’piperidyl)propyl-aminomethyl)-bisbenzo-4,7-phenanthroline, Marie-Paule Teulade-Fichou, David M. Perrin, Alexandre Boutourine, Jean Pierre Vigneron, Olivier Baudoin, Therese Garestier, Jean-Marie Lehn, and Claude Helene. J. Am. Chem. Soc. 2001 123: 9283-9292.

16) Bridging the Gap Between Proteins and Nucleic Acids: A Metal Independent RNaseA Mimic with Two Protein-like Functionalities David M. Perrin, Therese Garestier, and Claude Helene. J. Am. Chem. Soc. 2001 123: 1556-1563.

15) Nucleic Acids as Ligands and Catalysts – Landmarks and Limitations, Looking to the Future David M. Perrin. (Invited Review) Combinatorial Chemistry and High Throughput Screening 2000 3: 243-269.

14) Expanding the Catalytic Repertoire of Nucleic Acid Catalysts: Simultaneous Incorporation of Two Modified Deoxyribonucleotide Triphosphates Bearing Ammonium and Imidazolyl Functionalities: David M. Perrin, Therese Garestier, and Claude Helene. Nucleosides&Nucleotides 1999 18: 377-391.

Journals (from my graduate work)

13) Artificial Nucleases C.-H. Betty Chen, Lisa Milne, Ralf Landgraf, David M. Perrin, and David S. Sigman, ChemBioChem 2001 2: 735-740.

12) An Approach to Gene-specific Transcription Inhibition Using Oligonucleotides Complementary to the Template Strand of the Open Complex. Lisa Milne, Yue Xu, David M. Perrin, and David S. Sigman, Proc. Natl. Acad. Sci. USA. 2000 97: 3136-3141.

11) Gene Specific Transcription Inhibitors; Oligoribonucleotides Complementary to the Template Strand of Transcription Start Sites, David M. Perrin, Lori Pearson, Yue Xu, B. Chi-hong Chen, and David S. Sigman, J. Am. Chem. Soc. 1997 119: 5746-5747.

10) Recognition of Tetrahedral 1,10-Phenanthroline-Cuprous Chelates by Transcriptionally Active Complexes Does Not Depend on the Sequence of the Promoter. James Gallagher, David M. Perrin, Lisa Chan, Elizabeth Kwong, and David S. Sigman, Chemistry and Biology 1996 3: 739-746.

9) Optimizing the Targeted Chemical Nuclease Activity of 1,10 Phenanthroline-Copper via Substituent Effects, James J. Gallagher, Clark Q. Pan, Young-Moon Cho, David M. Perrin, Ralf Landgraf and David S. Sigman, Bioconj. Chem. 1996 7: 413-420.

8) Kinetic Characterization of Transcriptional Inhibition by the 2:1 Cuprous Chelate of 5-Phenyl-Neocuproine, David M. Perrin, Van M. Hoang, Yue Xu, and David S. Sigman, Biochemistry 1996 35: 5318-5326.

7) Helix Packing of Lactose Permease in Escherichia coli Studied by Site-Directed Chemical Cleavage, Jianhua Wu, David M. Perrin, David S. Sigman, and H. Ronald Kaback, Proc. Natl. Acad. Sci. USA 1995 92: 9186-9190.

6) Inhibition of Eucaryotic Transcription Units by the 2:1 Cuprous Chelate of Neocuproine, David M. Perrin, Lori L. Pearson, Abhijit Mazumder, and David S. Sigman, Gene 1994 149: 173-178.

5) Inhibition and Site-Specific Scission of a Kinetically Competent Transcription Complex Targeted by a Complementary Pentaribonucleotide, David M. Perrin, Abhijit Mazumder, Farshid Sadeghi, and David S. Sigman, Biochemistry 1994 33: 3848-3854.

4) Interactions of Transcription Inhibitors with the E.coli RNA polymerase-LacUV-5 Promoter Open-Complex, Abhijit Mazumder, David M. Perrin, David McMillen, and David S. Sigman, Biochemistry 33: 1994 2262-2268.

3) A Transcription Inhibitor Specific For Unwound DNA in RNA Polymerase-Promoter Open Complexes, Abhijit Mazumder, David M. Perrin, Karen J. Watson, and David S. Sigman, Proc. Natl. Acad. Sci. USA 1993 90: 8140-8144.

2) Chemical Nucleases, David S. Sigman, Abhijit Mazumder, and David M.Perrin, Chem. Rev. 1993 93: 2296-2316.

1) Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. Bradley S. Fletcher, Dean A. Kujubu, David M. Perrin, and Harvey R. Herschman, J. Biol. Chem. 1992 267: 4338-4344.